Substoichiometric inhibition of Aβ1–40 aggregation by a tandem Aβ40–1-Gly8-1-40 peptide
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چکیده
منابع مشابه
Inhibition of beta-amyloid(1-40) Peptide Aggregation and Neurotoxicity by Citrate.
The accumulation of beta-amyloid (Abeta) aggregates is a characteristic of Alzheimer's disease (AD). Furthermore, these aggregates have neurotoxic effects on cells, and thus, molecules that inhibit Abeta aggregate formation could be valuable therapeutics for AD. It is well known that aggregation of Abeta depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of Abeta, ...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2010
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.05.144